Bernard L Trumpower Selected Research

Atovaquone (Mepron)

5/2011	Design of anti-parasitic and anti-fungal hydroxy-naphthoquinones that are less susceptible to drug resistance.
1/2010	Probing binding determinants in center P of the cytochrome bc(1) complex using novel hydroxy-naphthoquinones.
10/2007	Modeling the molecular basis of atovaquone resistance in parasites and pathogenic fungi.
4/2007	Parameters determining the relative efficacy of hydroxy-naphthoquinone inhibitors of the cytochrome bc1 complex.
4/2005	Cytochrome b mutations that modify the ubiquinol-binding pocket of the cytochrome bc1 complex and confer anti-malarial drug resistance in Saccharomyces cerevisiae.
1/2004	Molecular basis for atovaquone resistance in Pneumocystis jirovecii modeled in the cytochrome bc(1) complex of Saccharomyces cerevisiae.
8/2003	Molecular basis for atovaquone binding to the cytochrome bc1 complex.

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Bernard L Trumpower Research Topics

Disease

5	Falciparum Malaria (Plasmodium falciparum Malaria) 05/2011 - 08/2003
5	Malaria 10/2007 - 01/2004
3	Pneumonia (Pneumonitis) 05/2011 - 01/2004
3	Toxoplasmosis 05/2011 - 08/2003
3	Pneumocystis Pneumonia (Pneumocystis carinii Pneumonia) 10/2007 - 08/2003
1	Mycoses (Diseases, Fungus) 05/2011
1	African Trypanosomiasis (Nagana) 10/2004
1	Infections 09/2003

Drug/Important Bio-Agent (IBA)

7	Atovaquone (Mepron)FDA Link 05/2011 - 08/2003
4	Cytochromes b (Cytochrome b)IBA 10/2007 - 09/2003
2	NaphthoquinonesIBA 05/2011 - 04/2007
1	Electron Transport Complex III (Coenzyme Q-Cytochrome-c Reductase)IBA 04/2005
1	Pharmaceutical PreparationsIBA 04/2005
1	furamidine (DB75)IBA 10/2004
1	ProdrugsIBA 10/2004
1	lawsoneIBA 08/2003